What are NAD and NAD + patches?
NAD is an acronym for nicotinamide adenine dinucleotide, and its oxidized form is referred to as NAD+. It controls many important chemical reactions in our body and offers many health benefits.
Studies have shown that NAD level falls in our body as we age, resulting in many complications like diabetes, obesity, fatty liver, and dyslipidemia. (Okabe et al., 2019) It is necessary to replenish this level in order to promote health and longevity. (Rajman et al., 2018)
NAD+ has been shown to help in anxiety and mental health, prevent diabetes, fibromyalgia, and COVID-19 infection.
NAD level can be boosted naturally through diet , lifestyle changes or NAD+ supplementations. If you are the kind of person who only believes in natural stuff, check out What boosts NAD+ level naturally and 6 Foods naturally rich in NAD. The other easier and most effective way is by taking NAD+ supplements that are available in various forms like lozenges, transdermal patches, tablets, or infusions. NAD patches (also known as NAD plus patches) are trendy as they are very convenient to use and cost-effective.
What is longevity?
Longevity can be defined as a long duration of life. Aging is a natural course of the human body, and it is impossible to stop it. Anti-aging interventions aim to slow or delay the process of aging. Some of the factors that are associated with aging are :
- Oxidative stress
- Drop in NAD+ level
- Increase in CD38 level
- Mitochondrial dysfunction
Luckily, NAD+ patches help control all of these factors and delay the onset of aging. Read more about NAD and aging.
How do NAD patches support longevity?
- Sirtuins are known as anti-aging genes as they protect our bodies from age-related damage. An optimum working of Sirtuins is required to slow the aging process and promote longevity. NAD+ is an essential component of Sirtuins, and its deficiency reduces the functioning of the sirtuins and increases the risks of cardiac and metabolic diseases.
When Sirtuins activity of the cells is compromised, cells are not able to use their stored energy, and a premature aging sets in. (Grabowska et al., 2017)
Extensive research has been done to find the stimulators of the sirtuin activity, and Scientists have presented two solutions. The first one is a caloric restriction that has been shown to activate sirtuin activity and delay aging in mice and yeast. The second one is increasing the NAD level in the body as sirtuin requires NAD+ for proper functioning.
NAD+ patches increase the NAD level, boost sirtuins activity, and increase life span. (1, 2007)
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Oxidative stress plays a key role in the aging-related decline in physiological and biochemical functions. Oxidants such as hydrogen peroxide, reactive oxygen species, hydroxyl radical, and superoxide can damage DNA, lipids, and proteins if they remain unchecked. (Massudi et al., 2012)
NAD plus patches perform two functions; First, Increased NAD levels act as an antioxidant that prevents oxidative damage. Secondly, enzymes mediated by NAD+ help repair the DNA and restore its function if DNA is damaged.
- Improves Mitochondrial Dysfunction
Mitochondria are the powerhouse of cells and provide energy for all the chemical reactions. Mitochondrial dysfunction is considered the hallmark of aging. (Schultz & Sinclair, 2016)
NAD acts as a carrier of electrons and helps the mitochondria make ATP. When our body is deficient in NAD, the process of making the energy stops, and so does the activity of many vital enzymes.
- Stabilize Telomerase length
Telomerase is a section of the DNA that is located at the end of the chromosome. It protects the chromosomes during DNA replication from damage. Telomerase becomes shorter every time a cell divide. Length of telomerase is a marker of aging and is a predictor of many diseases. As our cells continuously replicate, the telomerase becomes shorter and shorter until they disappear completely. (Erdem et al., 2021) Cancer cells are able to avoid aging by stabilizing the telomerase length. (Shay, 2016) Many studies have shown that NAD+ administration (by NAD patches) can stabilize telomerase length, decrease DNA damage and prevent telomerase-dependent disease. (Amano et al., 2019)
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